Publikationer
December 2024
Understanding Paralogous Epilepsy-Associated GABAA Receptor Variants: Clinical Implications, Mechanisms, and Potential Pitfalls
Kan ASH, Kusay AS, Mohammadi NA, Lin SXN, Liao VWY, Lesca G, Souci S, Milh M, Christophersen P, Chebib M, Møller RS, Absalom NL, Jensen AA, Ahring PK. Proc Natl Acad Sci U S A. 2024 Dec 10;121(50):e2413011121. doi: 10.1073/pnas.2413011121. PMID: 39642202
August 2024
Distinct Neurodevelopmental and Epileptic Phenotypes Associated with Gain- and Loss-of-Function GABRB2 Variants
Mohammadi NA, Ahring PK, Liao VWY, Chua HC, Ortiz de la Rosa S, Johannesen KM, Michaeli-Yossef Y, Vincent-Devulder A, Meridda C, Bruel AL, Rossi A, Patel C, Klepper J, Bonanni P, Minghetti S, Trivisano M, Specchio N, Amor D, Auvin S, Baer S, Meyer P, Milh M, Salpietro V, Maroofian R, Lemke JR, Weckhuysen S, Christophersen P, Rubboli G, Chebib M, Jensen AA, Absalom NL, Møller RS. EBioMedicine. 2024 Aug;106:105236. doi: 10.1016/j.ebiom.2024.105236. PMID: 38996765
December 2023
The Shortcoming of Using Glibenclamide in Exploratory Clinical Headache Provocation Studies
Christophersen P, Dyhring T. Cephalalgia. 2023 Dec;43(12):03331024231219475. doi: 10.1177/03331024231219475. PMID: 38064318
February 2023
Pharmacological Profiling of KATP Channel Modulators: An Outlook for New Treatment Opportunities for Migraine
Dyhring T, Jansen-Olesen I, Christophersen P, Olesen J. Pharmaceuticals (Basel). 2023 Feb 1;16(2):225. doi: 10.3390/ph16020225. PMID: 37259373
September 2022
Retroviral Glycoprotein-Mediated Immune Suppression via the Potassium Channel KCa3.1 – A New Strategy for Amelioration of Inflammatory Bowel Diseases
Laska MJ, Moeller JB, Graversen JH, Strøbæk D, Blomster L, Christophersen P, Bahrami S. Clin Immunol. 2022 Sep;242:109081. doi: 10.1016/j.clim.2022.109081. PMID: 35905828
May 2022
Randomized Controlled Trial of Tesomet for Weight Loss in Hypothalamic Obesity
Huynh K, Klose M, Krogsgaard K, Drejer J, Byberg S, Madsbad S, Magkos F, Aharaz A, Edsberg B, Tfelt-Hansen J, Astrup AV, Feldt-Rasmussen U. Eur J Endocrinol. 2022 May 9;186(6):687–700. doi: 10.1530/EJE-21-0972. PMID: 35294397
October 2020
Four Phase 1 Trials to Evaluate the Safety and Pharmacokinetic Profile of Single and Repeated Dosing of SCO-101 in Adult Male and Female Volunteers
Bergmann TK, Stage TB, Stenvang J, Christophersen P, Jacobsen TA, Roest NL, Vestlev PM, Brünner N. Basic Clin Pharmacol Toxicol. 2020 Oct;127(4):329–337. doi: 10.1111/bcpt.13466. PMID: 32628359
April 2020
Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABAA Receptors in a Rat Model of Essential Tremors
Amrutkar DV, Dyhring T, Jacobsen TA, Larsen JS, Sandager-Nielsen K. Cerebellum. 2020 Apr;19(2):265–274. doi: 10.1007/s12311-020-01106-w. PMID: 31989440
July 2020
Expression of α3β2β4 Nicotinic Acetylcholine Receptors by Rat Adrenal Chromaffin Cells Determined Using Novel Conopeptide Antagonists
Hone AJ, Rueda-Ruzafa L, Gordon TJ, Gajewiak J, Christensen S, Dyhring T, Albillos A, McIntosh JM. J Neurochem. 2020 Jul;154(2):158–176. doi: 10.1111/jnc.14966. PMID: 31967330
April 2020
Characterization of AN6001, a Positive Allosteric Modulator of α6β2-Containing Nicotinic Acetylcholine Receptors
van Hout M, Klein J, Ahring PK, Brown DT, Thaneshwaran S, Dos Santos AB, Jensen AA, Kohlmeier KA, Christophersen P, Dyhring T. Biochem Pharmacol. 2020 Apr;174:113788. doi: 10.1016/j.bcp.2019.113788. PMID: 31887290
April 2020
Characterization of AN317, a Novel Selective Agonist of α6β2-Containing Nicotinic Acetylcholine Receptors
Sandager-Nielsen K, Ahring PK, Klein J, van Hout M, Thaneshwaran S, Dos Santos AB, Jacobsen TA, Amrutkar DV, Peters D, Jensen AA, Kohlmeier KA, Christophersen P, Dyhring T. Biochem Pharmacol. 2020 Apr;174:113786. doi: 10.1016/j.bcp.2019.113786. PMID: 31887288
January 2020
Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels
Brown BM, Shim H, Christophersen P, Wulff H. Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:219–240. doi: 10.1146/annurev-pharmtox-010919-023420. PMID: 31337271
October 2019
The Delta-Subunit Selective GABAA Receptor Modulator DS2 Improves Stroke Recovery via an Anti-Inflammatory Mechanism
Neumann S, Boothman-Burrell L, Gowing EK, Jacobsen TA, Ahring PK, Young SL, Sandager-Nielsen K, Clarkson AN. Front Neurosci. 2019 Oct 29;13:1133. doi: 10.3389/fnins.2019.01133. PMID: 31736685
September 2019
Accurate and Affordable Assessment of Physiological and Pathological Tremor in Rodents Using the Accelerometer of a Smartphone
Carlsen EMM, Amrutkar DV, Sandager-Nielsen K, Perrier JF. J Neurophysiol. 2019 Sep 1;122(3):970–974. doi: 10.1152/jn.00281.2019. PMID: 31291169
May 2019
Antibodies and Venom Peptides: New Modalities for Ion Channels
Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. Nat Rev Drug Discov. 2019 May;18(5):339–357. doi: 10.1038/s41573-019-0013-8. PMID: 30728472
October 2018
Identification of New Molecular Targets for PET Imaging of the Microglial Anti-Inflammatory Activation State
Villa A, Klein B, Janssen B, Pedragosa J, Pepe G, Zinnhardt B, Vugts DJ, Gelosa P, Sironi L, Beaino W, Damont A, Dollé F, Jego B, Winkeler A, Ory D, Solin O, Vercouillie J, Funke U, Laner-Plamberger S, Blomster LV, Christophersen P, Vegeto E, Aigner L, Jacobs A, Planas AM, Maggi A, Windhorst AD. Theranostics. 2018 Oct;8(19):5400–5418. doi: 10.7150/thno.25572. PMID: 30555554
July 2017
Potassium Channel Expression and Function in Microglia: Plasticity and Possible Species Variations
Nguyen HM, Blomster LV, Christophersen P, Wulff H. Channels (Austin). 2017 Jul;11(4):305–315. doi: 10.1080/19336950.2017.1300738. PMID: 28277939
February 2017
Attenuation of Nicotine Taking and Seeking in Rats by the Stoichiometry-Selective Alpha4Beta2 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator NS9283
Maurer JJ, Sandager-Nielsen K, Schmidt HD. Psychopharmacology (Berl). 2017 Feb;234(3):475–484. doi: 10.1007/s00213-016-4475-7. PMID: 27844094
December 2016
Quantification of the Functional Expression of the Ca2+-Activated K+ Channel KCa3.1 on Microglia from Adult Human Neocortical Tissue
Blomster LV, Strøbaek D, Hougaard C, Klein J, Pinborg LH, Mikkelsen JD, Christophersen P. Glia. 2016 Dec;64(12):2065–2078. doi: 10.1002/glia.23040. PMID: 27470924
September 2016
A Pharmacological Assessment of Agonists and Modulators at α4β2γ2 and α4β2δ GABAA Receptors: The Challenge in Comparing Apples with Oranges
Ahring PK, Bang LH, Jensen ML, Strøbæk D, Hartiadi LY, Chebib M, Absalom N. Pharmacol Res. 2016 Sep;111:563–576. doi: 10.1016/j.phrs.2016.05.014. PMID: 27178730
June 2016
Delineation of the Functional Properties and the Mechanism of Action of TMPPAA, an Allosteric Agonist and Positive Allosteric Modulator of 5-HT3 Receptors
Gasiorek A, Trattnig SM, Ahring PK, Kristiansen U, Frølund B, Frederiksen K, Jensen AA. Biochem Pharmacol. 2016 Jun 15;110–111:92–108. doi: 10.1016/j.bcp.2016.04.004. PMID: 27086281
February 2016
NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats
Munro G, Christensen JK, Erichsen HK, Dyhring T, Demnitz J, Dam E, Ahring PK. CNS Neurosci Ther. 2016 Feb;22(2):135–145. doi: 10.1111/cns.12487. PMID: 26663905
November 2015
Recent Developments in Ion Channel Pharmacology
Wulff H, Christophersen P. Channels (Austin). 2015;9(6):335. doi: 10.1080/19336950.2015.1077650. PMID: 26646476
November 2015
Pharmacological Gating Modulation of Small- and Intermediate-Conductance Ca2+-Activated K+ Channels (KCa2.x and KCa3.1)
Christophersen P, Wulff H. Channels (Austin). 2015;9(6):336–343. doi: 10.1080/19336950.2015.1071748. PMID: 26217968
October 2015
Acetylcholine-Binding Protein Engineered to Mimic the α4–α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface-Specific Interactions Important for Binding and Activity
Shahsavar A, Ahring PK, Olsen JA, Krintel C, Kastrup JS, Balle T, Gajhede M. Mol Pharmacol. 2015 Oct;88(4):697–707. doi: 10.1124/mol.115.098061. PMID: 26180047
May 2015
Engineered α4β2 Nicotinic Acetylcholine Receptors as Models for Measuring Agonist Binding and Effect at the Orthosteric Low-Affinity α4–α4 Interface
Ahring PK, Olsen JA, Nielsen EØ, Peters D, Pedersen MH, Rohde LA, Kastrup JS, Shahsavar A, Indurthi DC, Chebib M, Gajhede M, Balle T. Neuropharmacology. 2015 May;92:135–145. doi: 10.1016/j.neuropharm.2014.12.035. PMID: 25595102
February 2015
GABAA α5 Subunit-Containing Receptors Do Not Contribute to Reversal of Inflammatory-Induced Spinal Sensitization as Indicated by the Unique Selectivity Profile of the GABAA Receptor Allosteric Modulator NS16085
de Lucas AG, Ahring PK, Larsen JS, Rivera-Arconada I, Lopez-Garcia JA, Mirza NR, Munro G. Biochem Pharmacol. 2015 Feb 1;93(3):370–379. doi: 10.1016/j.bcp.2014.12.010. PMID: 25542996
September 2014
Structural and Functional Studies of the Modulator NS9283 Reveal Agonist-Like Mechanism of Action at α4β2 Nicotinic Acetylcholine Receptors
Olsen JA, Ahring PK, Kastrup JS, Gajhede M, Balle T. J Biol Chem. 2014 Sep 5;289(36):24911–24921. doi: 10.1074/jbc.M114.568097. PMID: 24982426
May 2013
Anti-Hypertensive Treatment Preserves Appetite Suppression while Preventing Cardiovascular Adverse Effects of Tesofensine in Rats
Bentzen BH, Grunnet M, Hyveled-Nielsen L, Sundgreen C, Buus Lassen J, Hansen HH. Obesity (Silver Spring). 2013 May;21(5):985–992. doi: 10.1002/oby.20122. PMID: 23784901
Posters & Presentationer
October 2025
Mechanism of Action, Preclinical Efficacy, and Safety Evaluation of ACP-711 (SAN711), a Novel GABAA Subunit α3 Selective Modulator
Amrutkar DV,¹ Sandager-Nielsen K,¹ Dyhring T,¹ Jacobsen TA,¹ Larsen JS,¹ Muglia P,¹ Pathak S,² Hofbauer RK.² ¹Saniona A/S, Glostrup, Denmark; ²Acadia Pharmaceuticals, Inc., Princeton, NJ, USA. Session OPP9, Abstract LBA9. International Parkinson and Movement Disorder Society® Congress, Honolulu, Hawaii, October 5–9, 2025.
November 2023
Selective Activation of Alpha 3-Containing GABA-A Receptors Blocks Absence Seizures and Increases Sleep Spindles
Crunelli V, Morais TP, David F, Atherton Z, Delicata F, Di Giovanni G, Jacobsen TA, Larsen JS, Sandager-Nielsen K. Program No. PSTR526.08. Society for Neuroscience Annual Meeting, Washington D.C., November 2023.
June 2021
SAN711, a Selective GABAA α3 Receptor Positive Allosteric Modulator as a Novel Treatment for Trigeminal Neuralgia
Amrutkar DV,¹ Dyhring T,¹ Jacobsen TA,¹ Carson DS,² Larsen JS,¹ Sandager-Nielsen K.¹ ¹Saniona A/S, Glostrup, Denmark; ²Saniona, Inc., Waltham, MA, USA. ePresentation EPR-151. European Journal of Neurology 28 (Suppl. 1). 7th Congress of the European Academy of Neurology, virtual, June 19–22, 2021.
April 2021
Comparison of the Novel KCa3.1 Inhibitor SAN903 with Nintedanib and Pirfenidone in a Model of Idiopathic Pulmonary Fibrosis
Amrutkar DV,¹ Boddum JK,¹ Jacobsen TA,¹ Carson DS,² Brown D,¹ Strøbæk D,¹ Christophersen P.¹ ¹Saniona A/S, Glostrup, Denmark; ²Saniona, Inc., Waltham, MA, USA. Abstract ID: L5029. Experimental Biology 2021, April 2021.
September 2020
A Randomized-Controlled Trial of Tesomet Resulted in Significant Weight Loss in Hypopituitary Patients with Hypothalamic Obesity
Huynh K, Klose M, Krogsgaard K, Drejer J, Byberg S, Madsbad S, Magkos F, Aharaz A, Edsberg B, Astrup A, Feldt-Rasmussen U. Endocrine Abstracts. 2020;70:AEP1073. doi: 10.1530/endoabs.70.AEP1073. European Congress of Endocrinology, virtual, September 5–9, 2020.
November 2019
Tesomet – A New Treatment Opportunity in Prader-Willi Syndrome: Results from Phase 2a Exploratory Studies in Adult and Adolescent Patients
Torok D, Kolouskova S, Walter P, Edsberg B, Dvorak R. 10th International Prader-Willi Syndrome Organization Conference, Havana, Cuba, November 13–17, 2019. Abstract p. 47.
September 2018
SAN711, a Novel GABAA α2/3 Subtype Selective Positive Allosteric Modulator for Treatment of Neuropathic Pain and Chronic Pruritus
Amrutkar DV, Dyhring T, Jacobsen TA, Larsen JS, Sandager-Nielsen K. Saniona A/S, Ballerup, Denmark. Poster ID: 471099. IASP World Congress on Pain, Boston, USA, September 2018.
November 2016
A New Simple, Automatic and Non-Invasive Method for Measurement of Chemically Induced Tremors in Rats
Amrutkar DV, Jacobsen TA, Sandager-Nielsen K. Saniona A/S, Ballerup, Denmark. Posterboard No. I28. Society for Neuroscience Annual Meeting, San Diego, USA, November 2016.
November 2015
AN363, a Novel GABAA α2/3/5 Subtype Selective Positive Allosteric Modulator for Treatment of Chronic Pain
Amrutkar DV, Ahring PK, Dyhring T, Nielsen KS, Jacobsen TA, Larsen JS. Posterboard No. I28. Society for Neuroscience Annual Meeting, Chicago, USA, November 2015.