{"id":7911,"date":"2024-01-10T18:39:50","date_gmt":"2024-01-10T17:39:50","guid":{"rendered":"https:\/\/saniona.com\/?page_id=7911"},"modified":"2026-03-30T12:15:25","modified_gmt":"2026-03-30T10:15:25","slug":"san2465","status":"publish","type":"page","link":"https:\/\/saniona.com\/sv\/var-pipeline\/san2465\/","title":{"rendered":"SAN2465"},"content":{"rendered":"

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V\u00c5R PIPELINE<\/a><\/h6>\n

SAN2465 – Snabbverkande anitdepressivt l\u00e4kemedel\u00a0<\/p>\n<\/div>\n

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SAN2465<\/h1>\n

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Snabbverkande antidepressivt l\u00e4kemedel utan psykotropa biverkningar<\/h2>\n

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SAN2465 \u00e4r en mycket kraftfull och selektiv negativ allosterisk modulator (NAM) av receptorer som inneh\u00e5ller GABAA<\/sub> \u03b15, med en farmakologisk profil som skiljer sig fr\u00e5n s\u00e5v\u00e4l konventionella antidepressiva l\u00e4kemedel som nya NMDA-antagonister och psykedeliska pr\u00f6vningsl\u00e4kemedel. \u00a0<\/p>\n

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Hur SAN2465 fungerar<\/h3>\n

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SAN2465 har testats i kronisk mild stress-modellen av depression, vilken allm\u00e4nt betraktas som den djurmodell av depression som har b\u00e4st validitet och potentiell \u00f6verf\u00f6ringsbarhet till sjukdom hos m\u00e4nniska. I modellen har SAN2465 p\u00e5visat snabb och best\u00e5ende h\u00e4vning av depressionsliknande symptom som inducerats av kronisk stress, d\u00e4ribland anhedoni, \u00e5ngest och kognitiv neds\u00e4ttning. Den antidepressiva effekten p\u00e5minner i sitt intr\u00e4de och sin robusthet om ketamin, som anv\u00e4ndes som positiv kontroll i studien. Data indikerar att SAN2465 kan ge snabb antidepressiv effekt liknande vad som observerats f\u00f6r ketamin och esketamin (Spravato\u2122), d\u00e4r klinisk respons har p\u00e5visats inom timmar efter patientens f\u00f6rsta dos. I motsats till ketamin och esketamin f\u00f6rv\u00e4ntas den negativa moduleringen av GABAA<\/sub> a5-receptorer dock inte orsaka n\u00e5gra betydande biverkningar, d\u00e5 uttrycket av dessa receptorer \u00e4r mer lokaliserat och i huvudsak begr\u00e4nsas till limbiska omr\u00e5den.<\/p>\n

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Denna innovativa metod f\u00f6r behandling av egentlig depression har allts\u00e5 en verkningsmekanism som skiljer sig avsev\u00e4rt fr\u00e5n konventionella antidepressiva l\u00e4kemedel, och den har potential att bli ett first-in-class<\/em> snabbverkande antidepressivt l\u00e4kemedel utan de omfattande biverkningar som f\u00f6rknippas med esketamin.<\/p>\n

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STATUS F\u00d6R SAN2465<\/h5>\n

SAN2465 \u00e4r p\u00e5 v\u00e4g mot fas 1-studier under 2026<\/p>\n

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V\u00c5R PIPELINE SAN2465 – Snabbverkande anitdepressivt l\u00e4kemedel\u00a0 SAN2465Snabbverkande antidepressivt l\u00e4kemedel utan psykotropa biverkningarSAN2465 \u00e4r en mycket kraftfull och selektiv negativ allosterisk modulator (NAM) av receptorer som inneh\u00e5ller GABAA \u03b15, med en farmakologisk profil som skiljer sig fr\u00e5n s\u00e5v\u00e4l konventionella antidepressiva l\u00e4kemedel som nya NMDA-antagonister och psykedeliska pr\u00f6vningsl\u00e4kemedel. \u00a0Hur SAN2465 fungerarSAN2465 har testats i kronisk mild […]<\/p>\n","protected":false},"author":7,"featured_media":4139,"parent":3689,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7911","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/7911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/comments?post=7911"}],"version-history":[{"count":0,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/7911\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media\/4139"}],"wp:attachment":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media?parent=7911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}