{"id":7699,"date":"2023-12-13T09:48:08","date_gmt":"2023-12-13T08:48:08","guid":{"rendered":"https:\/\/saniona.com\/?page_id=7699"},"modified":"2023-12-18T12:22:18","modified_gmt":"2023-12-18T11:22:18","slug":"tesofensin","status":"publish","type":"page","link":"https:\/\/saniona.com\/sv\/var-pipeline\/tesofensin\/","title":{"rendered":"Tesofensin"},"content":{"rendered":"

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V\u00c5R PIPELINE<\/a><\/h6>\n

Tesofensin<\/p>\n<\/div>\n

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Tesofensin<\/h1>\n

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Robust viktnedg\u00e5ng vid fetma<\/h2>\n

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Tesofensin \u00e4r en unik trefaldig monoamin\u00e5terupptagsh\u00e4mmare: ett effektivt l\u00e4kemedel f\u00f6r viktnedg\u00e5ng.<\/p>\n

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Hur Tesofensin fungerar<\/h3>\n

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Tesofensin \u00e4r en monoamin\u00e5terupptagsh\u00e4mmare som modulerar hj\u00e4rnans aktivitet genom att \u00f6ka niv\u00e5erna av tre neurotransmittorer \u2013 dopamin, serotonin och noradrenalin \u2013 som var och en \u00e4r intimt involverade i att reglera aptit, mats\u00f6kande beteende och metabolism. Den viktminskande effekten av tesofensin har bekr\u00e4ftats i en sex m\u00e5nader l\u00e5ng klinisk Fas 2-studie p\u00e5 patienter med fetma (TIPO-1-studien). TIPO-1-studien indikerar att tesofensin vid den f\u00f6rv\u00e4ntade rekommenderade dosen p\u00e5 0,50 mg per dag ger en viktminskning p\u00e5 10 procent eller mer p\u00e5 24 veckor, vilket \u00e4r i samma intervall som n\u00e5gra av de b\u00e4sta GLP-1 analogerna. Till skillnad fr\u00e5n GLP-1-analogerna tillhandah\u00e5lls tesofensin i tabletter och kommer inte att kr\u00e4va titrering. Fas 3-studien bekr\u00e4ftade den \u00f6vertygande effekt och gynnsamma s\u00e4kerhetsprofil f\u00f6r tesofensin vid fetma som tidigare observerats i Fas 2-studien.<\/p>\n

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Sanionas samarbetspartner Medix har slutf\u00f6rt ett Fas 3-program d\u00e4r daglig dosering av tesofensin (0,25 respektive 0,50 mg) studerades hos m\u00e4nniskor med fetma. Fas 3-studien bekr\u00e4ftade den \u00f6vertygande effekt och gynnsamma s\u00e4kerhetsprofil f\u00f6r tesofensin vid fetma som tidigare observerats i Fas 2-studien.<\/p>\n

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TESOFENSIN STATUS<\/h5>\n

Sanionas samarbetspartner Medix har l\u00e4mnat in en ans\u00f6kan om godk\u00e4nnande som nytt l\u00e4kemedel f\u00f6r behandling av patienter med fetma till det mexikanska l\u00e4kemedelsverket, COFEPRIS. I februari 2023 l\u00e4mnade COFEPRIS tekniska kommitt\u00e9 ett positivt yttrande om tesofensin som behandling av fetma.<\/p>\n

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V\u00c5R PIPELINE Tesofensin TesofensinRobust viktnedg\u00e5ng vid fetmaTesofensin \u00e4r en unik trefaldig monoamin\u00e5terupptagsh\u00e4mmare: ett effektivt l\u00e4kemedel f\u00f6r viktnedg\u00e5ng.Hur Tesofensin fungerarTesofensin \u00e4r en monoamin\u00e5terupptagsh\u00e4mmare som modulerar hj\u00e4rnans aktivitet genom att \u00f6ka niv\u00e5erna av tre neurotransmittorer \u2013 dopamin, serotonin och noradrenalin \u2013 som var och en \u00e4r intimt involverade i att reglera aptit, mats\u00f6kande beteende och metabolism. Den […]<\/p>\n","protected":false},"author":7,"featured_media":4139,"parent":3689,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7699","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/7699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/comments?post=7699"}],"version-history":[{"count":0,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/7699\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media\/4139"}],"wp:attachment":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media?parent=7699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}