{"id":7387,"date":"2023-02-20T11:11:43","date_gmt":"2023-02-20T10:11:43","guid":{"rendered":"https:\/\/saniona.com\/?page_id=7387"},"modified":"2026-03-30T12:16:09","modified_gmt":"2026-03-30T10:16:09","slug":"san2219","status":"publish","type":"page","link":"https:\/\/saniona.com\/sv\/var-pipeline\/san2219\/","title":{"rendered":"SAN2219"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” global_colors_info=”{}”][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.16″ _module_preset=”default” z_index=”1″ height=”56vh” height_tablet=”45vh” height_phone=”70vh” height_last_edited=”on|phone” global_colors_info=”{}”][et_pb_fullwidth_slider show_arrows=”off” use_bg_overlay=”off” admin_label=”Slider 03″ module_class=”home-slider-section single-pagebanner” _builder_version=”4.19.5″ _module_preset=”default” min_height=”56vh” min_height_tablet=”45vh” min_height_phone=”70vh” min_height_last_edited=”on|phone” animation_style=”fade” custom_css_slide_description=”animation-name: none;” global_colors_info=”{}”][et_pb_slide use_bg_overlay=”off” use_text_overlay=”off” admin_title=”Slider 01″ _builder_version=”4.19.5″ _module_preset=”default” header_level=”h6″ header_font=”Nunito Sans|600|on||||||” header_text_color=”#ffffff” header_font_size=”16px” header_line_height=”1.1em” body_font=”DM Serif Display||||||||” body_text_color=”#ffffff” body_font_size=”50px” body_line_height=”1.3em” background_enable_color=”off” background_image=”https:\/\/saniona.com\/wp-content\/uploads\/2021\/04\/saniona-san903.jpg” background_enable_image=”on” parallax=”on” button_alignment=”left” width=”92%” custom_padding=”180px||||false|false” custom_padding_tablet=”140px||||false|false” custom_padding_phone=”40px||||false|false” custom_padding_last_edited=”on|phone” header_text_color_tablet=”” header_text_color_phone=”#555758″ header_text_color_last_edited=”on|phone” body_font_size_tablet=”46px” body_font_size_phone=”40px” body_font_size_last_edited=”on|tablet” body_line_height_tablet=”54px” body_line_height_phone=”50px” body_line_height_last_edited=”on|tablet” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

\n
V\u00c5R PIPELINE<\/a><\/h6>\n

SAN2219<\/p>\n<\/div>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|tablet” module_class=”flower-section” _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(0,0,0,0)” custom_margin=”||||false|false” custom_padding=”14px||16px||false|false” custom_padding_tablet=”” custom_padding_phone=”” box_shadow_style=”preset3″ box_shadow_vertical=”-12px” box_shadow_spread=”-12px” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”||5px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/saniona.com\/wp-content\/uploads\/2021\/01\/Saniona_icon_lg_ltblue_new.png” alt=”Saniona Icon blue” title_text=”Saniona_icon_lg_ltblue_new” align_tablet=”” align_phone=”” align_last_edited=”on|phone” disabled_on=”on|off|off” _builder_version=”4.16″ _module_preset=”default” z_index=”-1″ width=”66%” width_tablet=”72%” width_phone=”” width_last_edited=”on|tablet” custom_margin=”-350px||-300px||false|false” custom_margin_tablet=”-280px||-300px||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” animation_style=”fade” animation_direction=”bottom” animation_duration=”1400ms” animation_delay=”200ms” scroll_rotating_enable=”on” scroll_rotating=”60|84|84|100|0\u00b0|30\u00b0|90\u00b0” module_alignment_tablet=”left” module_alignment_phone=”left” module_alignment_last_edited=”on|tablet” scroll_rotating_tablet=”65|84|84|100|0\u00b0|15\u00b0|90\u00b0” scroll_rotating_phone=”” scroll_rotating_last_edited=”on|tablet” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(0,0,0,0)” z_index=”60″ custom_padding=”16px||55px||false|false” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” header_text_color=”#1d7ecd” header_font_size=”48px” header_line_height=”1.2em” custom_margin=”||0px|||” header_font_size_tablet=”38px” header_font_size_phone=”32px” header_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

SAN2219<\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” header_text_color=”#1d7ecd” header_font_size=”48px” header_line_height=”1.2em” header_2_font=”Nunito Sans||||||||” header_2_text_color=”#1d7ecd” header_2_font_size=”30px” header_2_line_height=”1.2em” header_font_size_tablet=”38px” header_font_size_phone=”32px” header_font_size_last_edited=”on|desktop” header_2_font_size_tablet=”” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

God anfallskontroll utan biverkningar<\/h2>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” text_font_size=”20px” text_line_height=”1.4em” custom_margin=”14px|||||” text_font_size_tablet=”” text_font_size_phone=”18px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

SAN2219 \u00e4r en subtypsselektiv positiv allosterisk modulator (PAM) av GABAA<\/sub> \u03b12- \u03b13- och \u03b15 med receptorer speciellt utformade f\u00f6r att framkalla en robust kramph\u00e4mmande effekt genom att brett d\u00e4mpa \u00f6verdriven neuronaktivering i hj\u00e4rnan.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(150,199,240,0.3)” background_enable_image=”off” background_size=”contain” background_position=”top_right” custom_padding=”14px||6px||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.19.5″ _module_preset=”default” text_text_color=”#1d7ecd” header_3_text_color=”#174d69″ header_3_font_size=”48px” header_3_line_height=”1.1em” header_3_font_size_tablet=”” header_3_font_size_phone=”40px” header_3_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Hur SAN2219 fungerar<\/h3>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.6″ _module_preset=”default” background_enable_color=”off” background_enable_image=”off” background_size=”contain” background_position=”top_right” custom_padding=”32px||45px||false|false” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font_size=”18px” text_line_height=”1.4em” min_height=”137px” custom_margin=”20px|||||” global_colors_info=”{}”]<\/p>\n

Till skillnad fr\u00e5n SAN711, vars profil \u00e4r skr\u00e4ddarsydd f\u00f6r att avbryta absenser genom att f\u00f6rst\u00e4rka effekten av GABA \u03b13-receptorer, \u00e4r profilen f\u00f6r SAN2219 specifikt utformad f\u00f6r att ut\u00f6va bred kramph\u00e4mmande aktivitet genom att f\u00f6rst\u00e4rka effekten av GABAA<\/sub> \u03b12- och \u03b15-receptorer, i till\u00e4gg till GABA \u03b13-receptorerna. Eftersom det inte sker n\u00e5gon f\u00f6rst\u00e4rkning av receptorer som inneh\u00e5ller subtypen GABAA<\/sub> -\u03b11 f\u00f6rv\u00e4ntas de negativa effekter som medieras av icke-selektiva bensodiazepiner undvikas. Saniona anser att profilen f\u00f6r SAN2219 skulle kunna vara mycket effektiv f\u00f6r att avbryta akuta repetitiva anfall, d\u00e4r anfallen bryter ut trots att patienten st\u00e5r under behandling med kramph\u00e4mmande l\u00e4kemedel. Akuta upprepade anfall kr\u00e4ver omedelbar tillsyn. I avsaknad av snabb och effektiv behandling kan akuta upprepade anfall utvecklas till \u201dstatus epilepticus\u201d, en potentiellt livshotande anfallssituation. Bensodiazepiner utg\u00f6r standardbehandling att anv\u00e4ndas vid akuta repetitiva anfall, men anv\u00e4ndningen \u00e4r begr\u00e4nsad till tv\u00e5 doser per epileptiskt anfall och behandling av mer \u00e4n fem episoder per m\u00e5nad rekommenderas inte p\u00e5 grund av de begr\u00e4nsningar som \u00e4r f\u00f6rknippade med bensodiazepiner, inklusive risken f\u00f6r toleransutveckling.
SAN2219 visar potent och kraftig effekt i en rad olika modeller f\u00f6r epileptiska anfall hos gnagare vid flera indikationer, inklusive anfall med fokal start, generaliserade tonisk-kloniska anfall och generaliserade icke-motoriska anfall (absens).<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font_size=”18px” text_line_height=”1.4em” min_height=”137px” custom_margin=”20px|||||” global_colors_info=”{}”]<\/p>\n

Dessutom \u00e4r SAN2219 inte sederande i standardmodellen f\u00f6r bed\u00f6mning av sedering hos gnagare. SAN2219 f\u00f6rv\u00e4ntas d\u00e4rmed kunna h\u00e4mma akuta repetitiva anfall utan begr\u00e4nsningar i anv\u00e4ndningen av benzodiazepiner.<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.6″ _module_preset=”default” text_font_size=”18px” text_line_height=”1.5em” header_5_font=”Nunito Sans|800|||||||” header_5_text_color=”#ffffff” header_5_font_size=”22px” header_5_letter_spacing=”2px” background_color=”#ffc13f” custom_padding=”36px|50px|36px|30px|false|false” hover_enabled=”0″ border_radii=”on|20px|20px|20px|20px” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

STATUS F\u00d6R SAN2219<\/h5>\n

SAN2219 \u00e4r p\u00e5 v\u00e4g mot fas 1-studier under 2026<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

V\u00c5R PIPELINE SAN2219 SAN2219God anfallskontroll utan biverkningarSAN2219 \u00e4r en subtypsselektiv positiv allosterisk modulator (PAM) av GABAA \u03b12- \u03b13- och \u03b15 med receptorer speciellt utformade f\u00f6r att framkalla en robust kramph\u00e4mmande effekt genom att brett d\u00e4mpa \u00f6verdriven neuronaktivering i hj\u00e4rnan.Hur SAN2219 fungerarTill skillnad fr\u00e5n SAN711, vars profil \u00e4r skr\u00e4ddarsydd f\u00f6r att avbryta absenser genom att f\u00f6rst\u00e4rka […]<\/p>\n","protected":false},"author":7,"featured_media":4139,"parent":3689,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-7387","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/7387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/comments?post=7387"}],"version-history":[{"count":0,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/7387\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media\/4139"}],"wp:attachment":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media?parent=7387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}