{"id":3696,"date":"2021-03-09T02:15:29","date_gmt":"2021-03-09T02:15:29","guid":{"rendered":"http:\/\/saniona.com.linux18.curanetserver.dk\/tesomet\/"},"modified":"2023-02-17T10:36:59","modified_gmt":"2023-02-17T09:36:59","slug":"tesomet","status":"publish","type":"page","link":"https:\/\/saniona.com\/sv\/var-pipeline\/tesomet\/","title":{"rendered":"Tesomet"},"content":{"rendered":"

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\n
V\u00c5R PIPELINE<\/a><\/h6>\n

Tesomet<\/p>\n<\/div>\n

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Tesomet<\/h1>\n

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Tesofensine + metoprolol<\/h2>\n

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Pr\u00f6vningsl\u00e4kemedlet Tesomet \u00e4r en fastdoskombination av tesofensin (en trefaldig monoamin\u00e5terupptagsh\u00e4mmare) och metoprolol (en selektiv beta-1-blockerare). Sanionas Fas 2b-studier med Tesomet f\u00f6r hypotalamisk fetma och Prader-Willis syndrom har frivilligt pausats p\u00e5 grund av finansiella sk\u00e4l; denna paus \u00e4r inte relaterad till s\u00e4kerheten eller effekten av Tesomet. Saniona har r\u00e4ttigheterna till Tesomet i hela v\u00e4rlden och unders\u00f6ker aktivt m\u00f6jligheterna att avancera behandlingen globalt.<\/p>\n

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Hur Tesomet fungerar<\/h3>\n

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TESOMET<\/h5>\n

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fixed-dose combination
of tesofensine + metoprolol<\/p>\n

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Tesomet kombinerar tv\u00e5 aktiva substanser: tesofensin och metoprolol. Tesofensin \u00e4r en ny, propriet\u00e4r molekyl som har utvecklats av forskargruppen som grundade Saniona. Den verkar i hj\u00e4rnan genom att blockera \u00e5terupptaget av tre signalsubstanser inom gruppen monoaminer. N\u00e4r \u00e5terupptaget blockeras \u00f6kar halten av dessa signalsubstanser i hj\u00e4rnan, vilket minskar beg\u00e4ret efter mat, d\u00e4mpar aptiten och \u00f6kar \u00e4mnesoms\u00e4ttningens fettf\u00f6rbr\u00e4nning.<\/p>\n

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Administrering av enbart tesofensin har i kliniska studier visats leda till viktnedg\u00e5ng och har i allm\u00e4nhet tolererats v\u00e4l. Emellertid ledde vissa doseringar till f\u00f6rh\u00f6jd hj\u00e4rtfrekvens och \u00f6kat blodtryck. I Tesomet kombineras tesofensin med metoprolol, ett generiskt l\u00e4kemedel som anv\u00e4nds f\u00f6r att behandla h\u00f6gt blodtryck, k\u00e4rlkramp och hj\u00e4rtsvikt. Tesometkombinationen har visats ha en klart f\u00f6rb\u00e4ttrad kardiovaskul\u00e4r s\u00e4kerhetsprofil j\u00e4mf\u00f6rt med enbart tesofensin.<\/p>\n

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STATUS F\u00d6R TESOMET<\/h5>\n

Sanionas Fas 2b-studier med Tesomet f\u00f6r hypotalamisk fetma och Prader-Willis syndrom har frivilligt pausats p\u00e5 grund av finansiella sk\u00e4l; denna paus \u00e4r inte relaterad till s\u00e4kerheten eller effekten av Tesomet.<\/p>\n

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L\u00c4S MER OM…<\/h5>\n

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Hypotalamisk fetma (HO)<\/a><\/p>\n

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Prader-Willis syndrom (PWS) <\/a><\/p>\n

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V\u00c5R PIPELINE Tesomet TesometTesofensine + metoprololPr\u00f6vningsl\u00e4kemedlet Tesomet \u00e4r en fastdoskombination av tesofensin (en trefaldig monoamin\u00e5terupptagsh\u00e4mmare) och metoprolol (en selektiv beta-1-blockerare). Sanionas Fas 2b-studier med Tesomet f\u00f6r hypotalamisk fetma och Prader-Willis syndrom har frivilligt pausats p\u00e5 grund av finansiella sk\u00e4l; denna paus \u00e4r inte relaterad till s\u00e4kerheten eller effekten av Tesomet. Saniona har r\u00e4ttigheterna till Tesomet […]<\/p>\n","protected":false},"author":5,"featured_media":2335,"parent":3689,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-3696","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/comments?post=3696"}],"version-history":[{"count":0,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3696\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media\/2335"}],"wp:attachment":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media?parent=3696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}