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V\u00c5R VETENSKAPLIGA GRUND<\/a><\/h6>\n

Uppt\u00e4cktsprocessen<\/p>\n<\/div>\n

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Vad kr\u00e4vs f\u00f6r att uppt\u00e4cka ett nytt l\u00e4kemedel?<\/h1>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#1d7ecd” header_font_size=”48px” header_line_height=”1.2em” header_2_font=”Nunito Sans||||||||” header_2_text_color=”#1d7ecd” header_2_font_size=”30px” header_2_line_height=”1.2em” custom_margin=”||17px|||” header_font_size_tablet=”38px” header_font_size_phone=”32px” header_font_size_last_edited=”on|desktop” header_2_font_size_tablet=”” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Sanionas plattform f\u00f6r l\u00e4kemedelsuppt\u00e4ckt inom jonkanaler<\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font_size=”20px” text_line_height=”1.4em” custom_margin=”14px|||||” text_font_size_tablet=”” text_font_size_phone=”18px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Processen f\u00f6r att uppt\u00e4cka ett nytt l\u00e4kemedel och genomf\u00f6ra kliniska studier som styrker s\u00e4kerhet och effekt tar ofta m\u00e5nga \u00e5r och kostar hundratals miljoner dollar.1<\/sup><\/strong> Alla l\u00e4kemedelssatsningar kommer inte heller hela v\u00e4gen. Faktum \u00e4r att det har uppskattats att man m\u00e5ste forska fram mellan 5 000 och 10 000 f\u00f6reningar i uppt\u00e4cktsfasen (innan man har ett l\u00e4kemedel redo f\u00f6r pr\u00f6vning p\u00e5 m\u00e4nniska) f\u00f6r att hitta bara fem som \u00e4r tillr\u00e4ckligt lovande f\u00f6r att inleda klinisk utveckling.2\u00a0<\/sup>Det \u00e4r d\u00e4rf\u00f6r den erfarenhet och historia som finns inom Sanionas team av forskare \u00e4r s\u00e5 viktig. V\u00e5ra forskare har haft pionj\u00e4rsroller inom jonkanalsrelaterad forskning i \u00f6ver 20 \u00e5rs tid. Vi har utvecklat en propriet\u00e4r plattform f\u00f6r l\u00e4kemedelsuppt\u00e4ckt inom jonkanaler som har gett upphov till ett bibliotek omfattande mer \u00e4n 20 000 potentiella lead-molekyler med olika jonkanaler som m\u00e5l. Vi \u00e4r \u00f6vertygade om att vissa av dem kommer att resultera i nya l\u00e4kemedel \u2013 och den insats av tid och pengar som vi redan har gjort f\u00f6r att uppt\u00e4cka dem ger oss ett enormt f\u00f6rsteg framf\u00f6r m\u00e5nga uppstartsbolag<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font_size=”18px” text_line_height=”1.5em” header_5_font=”Nunito Sans|800|||||||” header_5_text_color=”#ffffff” header_5_font_size=”22px” header_5_letter_spacing=”2px” background_color=”#ffc13f” background_image=”https:\/\/saniona.com\/wp-content\/uploads\/2021\/01\/Saniona_icon_lg_gold.png” custom_padding=”45px|60px|45px|60px|false|false” custom_padding_tablet=”” custom_padding_phone=”30px|30px|30px|30px|false|false” custom_padding_last_edited=”on|phone” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{}”]<\/p>\n

FAST FACT<\/h5>\n

Jonkanaler spelar en avg\u00f6rande roll f\u00f6r ett stort antal av kroppens funktioner, bland annat musklernas och nervernas aktivitet. De anv\u00e4nds f\u00f6r att f\u00f6rflytta laddade joner som kalium eller klorid in i och ut ur celler. Modulering av jonkanaler \u00e4r en validerad metod f\u00f6r att behandla sjukdom och har anv\u00e4nts i l\u00e4kemedel mot diabetes, hypertoni, epilepsi med mera.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(150,199,240,0.3)” background_enable_image=”off” background_size=”contain” background_position=”top_right” custom_padding=”14px||6px||false|false” animation_style=”fade” global_colors_info=”{}”][et_pb_row column_structure=”1_4,1_2,1_4″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/saniona.com\/wp-content\/uploads\/2021\/04\/Saniona_icon_discovery-biology.png” title_text=”Saniona_icon_discovery-biology” show_bottom_space_tablet=”off” show_bottom_space_phone=”” show_bottom_space_last_edited=”on|tablet” align_tablet=”center” align_phone=”” align_last_edited=”on|tablet” _builder_version=”4.16″ _module_preset=”default” width=”85%” width_tablet=”40%” width_phone=”60%” width_last_edited=”on|phone” module_alignment=”center” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” custom_padding_tablet=”” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” module_alignment_tablet=”” module_alignment_phone=”” module_alignment_last_edited=”on|tablet” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font_size=”20px” text_line_height=”1.4em” header_3_font_size=”36px” min_height=”137px” custom_margin=”20px|||||” custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” text_font_size_tablet=”” text_font_size_phone=”18px” text_font_size_last_edited=”on|phone” header_3_font_size_tablet=”” header_3_font_size_phone=”32px” header_3_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Uppt\u00e4cktsbiologi<\/h3>\n

H\u00e4r b\u00f6rjar v\u00e5r process f\u00f6r att uppt\u00e4cka ett nytt l\u00e4kemedel. Vi identifierar f\u00f6rst vilken sjukdom vi vill behandla och b\u00f6rjar sedan unders\u00f6ka vilka jonkanalsm\u00e5l som har p\u00e5visade kopplingar till den sjukdomen.<\/p>\n

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F\u00f6rsta Biologisk S\u00e5llning av Substansbiblioteket<\/h3>\n

N\u00e4r vi har klarlagt vilka jonkanalsm\u00e5l vi beh\u00f6ver rikta in oss mot bygger vi upp cellprovningssystem f\u00f6r att s\u00e5lla fram substanser ur v\u00e5rt bibliotek som st\u00e4mmer \u00f6verens med m\u00e5let. De substanser som st\u00e4mmer med m\u00e5let kallar vi \u201dtr\u00e4ffar\u201d.<\/p>\n

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FAST FACT<\/h5>\n

V\u00e5r propriet\u00e4ra plattform f\u00f6r l\u00e4kemedelsuppt\u00e4ckt inom jonkanaler baserar sig p\u00e5 v\u00e5r sakkunskap inom utformning av analyssystem, elektrofysiologiska metoder, avancerade avbildningsmetoder och diverse andra propriet\u00e4ra tekniker, databaser och metoder.<\/p>\n

.<\/p>\n

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Uppt\u00e4cktskemi och in Vitro-<\/em>farmakologi Med Underst\u00f6d av Artificiell Intelligens (AI)<\/h3>\n

Vi utg\u00e5r fr\u00e5n tr\u00e4ffarna vi f\u00e5tt i substansbiblioteket och optimerar deras kemiska och biologiska egenskaper genom en iterativ l\u00e4kemedelskemisk process. Den h\u00e4r forskningen utf\u00f6r vi i provr\u00f6r i v\u00e5ra egna laboratorier. Vi beh\u00f6ver ocks\u00e5 optimera egenskaper som har att g\u00f6ra med l\u00e4kemedlets upptag, distribution i kroppen, metabolism och uts\u00f6ndring. Man kan s\u00e4ga att vi dels analyserar vilken verkan l\u00e4kemedlet har p\u00e5 kroppen, dels vad kroppen g\u00f6r med l\u00e4kemedlet (till exempel hur snabbt det oms\u00e4tts och bryts ned). Vi syntetiserar nya kemiska enheter med hj\u00e4lp av artificiell intelligens \u2013 ofta minst 1 000 stycken innan den iterativa processens upprepade cykler l\u00e5ter oss finna den optimala sammans\u00e4ttningen.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/saniona.com\/wp-content\/uploads\/2021\/04\/Saniona_icon_discovery-chemistry.png” title_text=”Saniona_icon_discovery-chemistry” disabled_on=”on|on|off” _builder_version=”4.16″ _module_preset=”default” width=”85%” module_alignment=”center” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(150,199,240,0.3)” background_enable_image=”off” background_size=”contain” background_position=”top_right” custom_padding=”2px||6px||false|false” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_4,1_2,1_4″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/saniona.com\/wp-content\/uploads\/2021\/04\/Saniona_icon_invivo-pharma.png” title_text=”Saniona_icon_invivo-pharma” align=”center” align_tablet=”” align_phone=”” align_last_edited=”on|tablet” _builder_version=”4.16″ _module_preset=”default” width=”85%” width_tablet=”40%” width_phone=”60%” width_last_edited=”on|phone” module_alignment=”center” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font_size=”20px” text_line_height=”1.4em” header_3_font_size=”36px” header_3_line_height=”1.2em” min_height=”137px” custom_margin=”20px|||||” custom_margin_tablet=”0px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” text_font_size_tablet=”” text_font_size_phone=”18px” text_font_size_last_edited=”on|phone” header_3_font_size_tablet=”” header_3_font_size_phone=”32px” header_3_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Farmakologi och Effekt in vivo<\/em><\/h3>\n

I det h\u00e4r skedet b\u00f6rjar vi unders\u00f6ka huruvida l\u00e4kemedlet kommer att ha en gynnsam effekt p\u00e5 den sjukdom vi har beslutat att behandla. Ut\u00f6ver det studerar vi i detalj vilken p\u00e5verkan l\u00e4kemedlet kan ha p\u00e5 hela kroppen, liksom relevanta v\u00e4vnader och organ. Vi analyserar ocks\u00e5 hur effekten korrelerar med m\u00e4ngden l\u00e4kemedel i blodprover f\u00f6r att uppskatta en l\u00e4mplig m\u00e4nsklig dos och hur doseringen b\u00f6r f\u00f6rdelas \u00f6ver dagen.<\/p>\n

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Preklinisk Utveckling<\/h3>\n

I den h\u00e4r fasen genomg\u00e5r den optimerade och utvalda substansen ett antal olika tester som har att g\u00f6ra med toxikologi (f\u00f6r att kartl\u00e4gga m\u00f6jliga biverkningar), formulering (f\u00f6r att best\u00e4mma om den ska ges som tablett, kapsel, injektion eller i annan form) och uppskalning (f\u00f6r att ta fram processer f\u00f6r att tillverka den i tillr\u00e4cklig m\u00e4ngd f\u00f6r kliniska studier). De h\u00e4r stegen genomf\u00f6r Saniona tillsammans med ett n\u00e4tverk av samarbetspartner.<\/p>\n

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Klinisk Utveckling<\/h3>\n

F\u00f6rst efter att alla dessa steg har slutf\u00f6rts framg\u00e5ngsrikt p\u00e5b\u00f6rjas kliniska pr\u00f6vningar, d\u00e4r komponenten utv\u00e4rderas p\u00e5 m\u00e4nniskor. F\u00f6r att l\u00e4ra dig mer om den kliniska utvecklingsprocessen, se v\u00e5r infografik f\u00f6r l\u00e4kemedelsutveckling p\u00e5 www.saniona.com<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” background_color=”#ffffff” background_enable_image=”off” background_size=”contain” background_position=”top_right” custom_padding=”2px||6px||false|false” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” custom_padding=”7px|||||” border_width_top=”1px” border_color_top=”#cfcfd3″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” ol_text_color=”#8b9091″ ol_font_size=”13px” ol_line_height=”1.4em” global_colors_info=”{}”]<\/p>\n

    \n
  1. Tufts Center for the Study of Drug Development. Impact Report. Vol. 20, No. 3, May\/June 2018.<\/li>\n
  2. Drug Discovery and Development. Britannica. https:\/\/www.britannica.com\/technology\/pharmaceutical-industry\/Obstacles-in-drug-development<\/a>. Last accessed February 2021.<\/li>\n<\/ol>\n

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    V\u00c5R VETENSKAPLIGA GRUND Uppt\u00e4cktsprocessen Vad kr\u00e4vs f\u00f6r att uppt\u00e4cka ett nytt l\u00e4kemedel?Sanionas plattform f\u00f6r l\u00e4kemedelsuppt\u00e4ckt inom jonkanalerProcessen f\u00f6r att uppt\u00e4cka ett nytt l\u00e4kemedel och genomf\u00f6ra kliniska studier som styrker s\u00e4kerhet och effekt tar ofta m\u00e5nga \u00e5r och kostar hundratals miljoner dollar.1 Alla l\u00e4kemedelssatsningar kommer inte heller hela v\u00e4gen. Faktum \u00e4r att det har uppskattats att […]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":3631,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-3674","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/comments?post=3674"}],"version-history":[{"count":0,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3674\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/pages\/3631"}],"wp:attachment":[{"href":"https:\/\/saniona.com\/sv\/wp-json\/wp\/v2\/media?parent=3674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}