Ion channels constitute a unique class of proteins that allow and control the passage of charged ions across the cell membrane. Activation of ion channels can modulate the potential difference across the cell membrane via the electrical current carried by movement of ions, and allow the recruitment of specific ions to intracellular targets. The highly coordinated opening and closing of ion channels governs the activity of all excitable cells including nerve cells, and thereby the overall performance of the brain and the immune system.

Saniona’s technology platform allows for investigating all types of ion channel drug targets. We have chosen to focus our research effort primarily around three classes of ion channels. These are GABAA receptors, nicotinic acetylcholine receptors and potassium channels.