Saniona and Cadent Therapeutics collaborate on developing activators of calcium-activated small conductance potassium channels (SK channels) for treatment of the neurological movement disorders, essential tremors and ataxia. Essential tremors are among the most common neurological disorders causing hand-shivering, whereas ataxia is a generic term for a group of orphan diseases of both spontaneous and hereditary origin characterized by severe coordination problems. For patients with spinocerebellar ataxia (SCA) and essential tremor, the firing pattern of neurons in the cerebellum have become dysregulated, resulting in the loss of motor control that impacts mobility and fine motor function.
CAD-1883 has been discovered in the research collaboration with Cadent Therapeutics. By changing the calcium sensitivity of the SK channels, CAD-1883 causes potassium current to flow at lower calcium concentrations, potentially restoring neuronal firing regularity and improving motor function.
A Phase 1 clinical study with CAD-1883 for treatment of spinocerebellar ataxia and essential tremor is currently ongoing.