Target Classes

GABAA Receptors

Profiles:
Subtype selectivity
Allosteric modulators
Novel modes of action
Novel binding sites
Indications:
Chronic Pain,
Anxiety,
Autism Spectrum disorders
Highlighted Program:
GABAA α2-3 selective positive allosteric modulators: a novel approach for treating neuropathic pain
 

Nicotinic Acetyl Choline Receptors

Profiles:
Subtype selectivity
Agonists
Allosteric modulators
Indications:
Parkinson's Disease,
Cognition deficits,
Alzheimers Disease, Schizophrenia
Highlighted Program:
Nicotinic α6 – selective positive allosteric modulators: a novel approach for treating Parkinson's Disease
 

Potassium Channels

Profiles:
Subtype selectivity
Activators
Allosteric modulators
Inhibitors
Indications:
Ataxia,
Inflammation,
Bipolar disorders
Highlighted Program:
Potassium channel activators for ataxia